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Prontogest Ampoule

Brand Name: Prontogest® Ampoule
Generic Name: Progesterone

When is Prontogest Ampoule prescribed?

Prontogest Ampoule is prescribed for and extra-gynecological surgery during pregnancy; risk of miscarriage; recurrent miscarriage; risk early delivery; hypermenorrhea, polymenorrhea, metrorrhagia, amenorrhea, hypomenorrhea, oligomenorrhea, premenstrual syndrome; prophylaxis of post-partum depression.

How should you take Prontogest Ampoule?

According to medical advice, Generally the following schedules may be used:
  • Risk of miscarriage:
    • 10 quarter: 100-200 mg per day for at least 7 days. Thereafter, maintenance therapy with 50 mg every other day for further 20 days.
    • 20 quarter: 100-200 mg per day for at least 7 days. Thereafter, 100 mg every other day for further 20 days.
  • Recurrent miscarriage: it is advisable to begin administration of Prontogest® Ampoule from the very beginning of gestation with the dosage of 50-100 mg two or three times a week. In particular the administration should be careful during the 3rd month of gestation when the natural secretion of progesterone decreases due to the involution of the corpus luteum.
  • Hypermenorrhea, polymenorrhea, metrorrhagia: endometrial scraping should precede hormone administration. The administration of Prontogest® Ampoule should begin some days before the onset of menses. The amount administered should not be less than 50 mg.
  • Amenorrhea, hypomenorrhea and oligomenorrhea: progesterone, alone or in association with FSH and LH, should be used only after the cause (hypophisis, uterus, ovary) has been diagnosed. According to some authors Prontogest® Ampoule should be administered at the dose 25 mg a day for 5 days a month, eventually associated to estrogens.
  • Surgery during pregnancy: 100-200 mg a day or as otherwise medically prescribed.
  • Pre-menstrual syndrome: The advice for severe cases is a daily treatment with 50mg from the 14th day of the cycle till the beginning of menses.
  • Prophylaxis of post-partum depression: after delivery, 2 ampoules of 100 mg of progesterone Prontogest® Ampoule per day during the first 7 days. Thereafter, the dosage may be reduced to 100 mg a day up to the re-appearance of menses. Then, from the 14th day of the cycle until the onset of menses, 50-10 mg per day The administration of progesterone can be then progressively reduced. in length of time as well as in dosage, up to complete relief of symptoms.

Prontogest ampoule is for intramuscular administration only

Special warning and precautions:

Symptoms of partial or total sight loss as well as of diplopia should be carefully monitored and the treatment is to be discontinued incase of proven papillar odema or lesion to retinal vessels. The same applies to early symptoms of thromboembolism either peripheral, cerebral or pulmonary. Subjects carrying abnormalities of endocrine or liver function tests: in such cases the treatment should be discontinued and the tests repeated two months later. Patients with epilepsy, asthma, kidney or heart failure should be carefully managed since progestin may impair water retention and glucose tolerance.

When Prontogest Ampoule shouldn't be prescribed?

Known hypersensitivity, gynecological bleeding of unknown origin, thrombophilic or thromboembolic disorders, severe liver failure

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